Triethyl Phosphate → Diethyl 2-chloro-5-fluoro-4-nitrobenzylphosphonate

Participants

Reaction Steps

1-(Bromomethyl)-2-chloro-5-fluoro-4-nitrobenzene (6.7 g, 18.62 mmol) and triethyl phosphate (5.64 mL) were heated in an oil bath for 3 hours at 140° C. The reaction mixture was concentrated and chromatographed on silica eluting with dichloromethane/methanol (1:0-1%) to give the title compound (4.06 g).

Provenance & Evidence