4-Nitrophenyl chloroformate → HCID 52919311, compound

Participants

Reaction Steps

A solution of 2-(4-((4-(4-amino-2,5-difluorobenzyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.311 mmol, 150 mg) and 4-nitrophenyl carbonochloridate (0.311 mmol, 62.7 mg) in tetrahydrofuran (5 mL) was stirred at room temperature for 30 minutes. 1-Amino-2-methylpropan-2-ol (0.622 mmol, 0.079 mL, 55.4 mg) was added and the reaction was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and the residue purified by column chromatography (eluent: 2-10% methanol in dichloromethane) to afford the title compound (89.5 mg). MS (ESI) m/z 598.2 [M+H]+

Provenance & Evidence