反应详情

tert-Butyl 4-(4-nitrophenylthio)piperidine-1-carboxylate (8.56 mmol, 2.8973 g) and palladium (3.77 mmol, 0.401 g) were combined in ethanol (30 mL) and the reaction mixture hydrogenated at 5 bar for 2 hours. The reaction mixture was filtered and concentrated under vacuum, reaction incomplete. Hydrogenation resumed with fresh palladium and left overnight. The reaction mixture was filtered and concentrated under vacuum to afford the title compound (2.86 g).

1. filtrationThe reaction mixture was filtered
2. concentrationconcentrated under vacuum, reaction incomplete
3. waitleft overnight
4. filtrationThe reaction mixture was filtered
5. concentrationconcentrated under vacuum