HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1,1,1,3,3,3-Hexafluoro-2-(4-((4-(methylamino)piperidin-1-yl)methyl)phenyl)propan-2-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperidin-4-yl(methyl)carbamate | HCID 86670960 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1,1,1,3,3,3-Hexafluoro-2-(4-((4-(methylamino)piperidin-1-yl)methyl)phenyl)propan-2-ol | HCID 86670959 | 93.1% |
Reaction Steps
A mixture of tert-butyl 1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)-piperidin-4-yl(methyl)carbamate (3.19 mmol, 1.5 g), dichloromethane (5 mL) and trifluoroacetic acid (5 mL) was stirred for 20 hours. Purification by SCX chromatography gave the title compound (1.1 g). MS (ESI) m/z 371.4 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108939B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-36a46946967e4f99b3a397206ae6540f |
| Source note | uspto-grants-2015_08 |