Potassium Carbonate → HCID 86670965, compound

Participants

Reaction Steps

A mixture of 4-(3-(cyclopropylmethyl)ureido)-N-methyl-N-(pyrrolidin-3-yl)benzamide (4.74 mmol, 1.5 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (4.74 mmol, 1.598 g) and potassium carbonate (7.11 mmol, 0.983 g) in acetonitrile (40 mL) was refluxed for 5 hours. The reaction was concentrated under reduced pressure and dichloromethane/methanol was added. The suspension was filtered and the filtrate was concentrated under reduced pressure. Chromatography on silica eluting with a gradient of dichloromethane/methanol gave the title compound (400 mg). MS (ESI) m/z 573.2 [M+H]+

Provenance & Evidence