N-bromobutanimide → HCID 86670966, compound

Participants

Reaction Steps

N-Bromosuccinimide (207 mg, 1.162 mmol) was added to a solution of 1,1,1,3,3,3-hexafluoro-2-m-tolylpropan-2-ol (300 mg, 1.162 mmol) and 2,2′-azobis(isobutyronitrile) (0.191 mg, 1.162 μmol) in carbon tetrachloride (6 mL). The mixture was refluxed for 18 hours and then concentrated under reduced pressure. The crude material was dissolved in diethyl ether and heptane, filtered through dicalite, and purified by silica chromatography (eluting with a solvent gradient from 2% ethyl acetate/98% heptane to 10% ethyl acetate/90% heptane) to afford the title compound (84 mg).

Provenance & Evidence