Sodium Iodide → HCID 86670967, compound

Participants

Reaction Steps

2-(3-(Bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (84 mg, 0.249 mmol) was added to a solution of 4-(3-(cyclopropylmethyl)ureido)-N-methyl-N-(piperidin-4-yl)benzamide (82 mg, 0.249 mmol), sodium iodide (15 mg, 0.100 mmol), and potassium carbonate (103 mg, 0.748 mmol) in acetonitrile (3 mL) and the solution was stirred at ambient temperature overnight. The reaction mixture was concentrated under vacuum, dissolved in dichloromethane, washed with water, and purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 3.5% methanol/96.5% dichloromethane) to afford the title compound (57 mg).

Provenance & Evidence