HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 515338Generated: October 30, 2026
Carbamic acid, 4-pyridinyl-, phenyl ester → 1-(4-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)phenyl)-3-(pyridin-4-yl)urea
https://huagongshe.com/reaction/515338
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Carbamic acid, 4-pyridinyl-, phenyl ester | HCID 11401617 | — |
| Reactant | 2-(4-((4-(4-Aminophenyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol | HCID 87303543 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-(1-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)phenyl)-3-(pyridin-4-yl)urea | HCID 86670968 | — |
Reaction Steps
Reaction 2: A mixture of 2-(4-((4-(4-aminophenyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.925 mmol, 400 mg) and phenyl pyridin-4-ylcarbamate (1.388 mmol, 297 mg) in dioxane was heated in a reactivial at 100° C. (heating block temperature) for 48 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09108939B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-f81a54b7a58847d2ac05949c4815432e |
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| Source note | uspto-grants-2015_08 |
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