Triethylamine → HCID 86670980, compound

Participants

Reaction Steps

(4-Aminophenyl)(1-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)benzyl)piperidin-4-yl)methanone (0.367 mmol, 169 mg) and 4-nitrophenyl chloroformate (0.367 mmol, 74.0 mg) were combined in tetrahydrofuran (2 mL) and stirred at room temperature for 1 hour. Oxetan-3-amine (0.734 mmol, 53.7 mg) and triethylamine (1.101 mmol, 111 mg) were added and the mixture stirred at room temperature overnight. The mixture was concentrated under reduced pressure and the resulting residue purified by basic HPLC to afford the title compound (43 mg). MS (ESI) m/z 560.2 [M+H]+.

Provenance & Evidence