p-Fluoronitrobenzene → HCID 67193925, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-fluoro-4-nitrobenzene (12.24 mmol, 1.726 g), 1-benzyl-N-methylpiperidin-4-amine (12.24 mmol, 2.5 g) and potassium carbonate (12.24 mmol, 1.691 g) was heated at 100° C. using an oil bath for 48 hours. The reaction mixture was allowed to cool to room temperature, diluted with dichloromethane and filtered. The filtrate was concentrated under vacuum to give the intermediate 1-benzyl-N-methyl-N-(4-nitrophenyl)piperidin-4-amine (3.8 g).

Provenance & Evidence