1,4-Dioxane → HCID 86670982, compound

Participants

Reaction Steps

2-(4-((4-((4-Aminophenyl)(methyl)amino)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.260 mmol, 120 mg) and phenyl pyridin-4-ylcarbamate (0.390 mmol, 84 mg) were combined in tetrahydrofuran (1 mL) and dioxane (1 mL) and heated to 100° C. overnight. The reaction mixture was concentrated under vacuum. The residue was purified by prep-HPLC (acidic conditions) and SCX chromatography to give the title compound (44.2 mg). MS (ESI) m/z 582.2 [M+H]+

Provenance & Evidence