Potassium Carbonate → HCID 86670984, compound

Participants

Reaction Steps

2-(4-(Bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (2.369 mmol, 1.141 mL, 798 mg), N-(2-fluoro-4-nitrophenyl)-N-methylpiperidin-4-amine (2.369 mmol, 600 mg) and potassium carbonate (7.11 mmol, 982 mg) were combined and stirred at 70° C. overnight in acetonitrile (50 mL). The reaction mixture was filtered and concentrated under vacuum. The residue was dissolved in ethyl acetate and washed with saturated sodium bicarbonate solution. The organic layer was separated, dried over magnesium sulfate and concentrated under vacuum to give the intermediate 1,1,1,3,3,3-hexafluoro-2-(4-((4-((2-fluoro-4-nitrophenyl)(methyl)amino)piperidin-1-yl)methyl)phenyl)propan-2-ol (1.5 g).

Provenance & Evidence