Triethylamine → HCID 86670989, compound

Participants

Reaction Steps

To a stirred solution of 2-(4-((4-(3-aminophenoxy)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (1.115 mmol, 500 mg) in dichloromethane was added 4-nitrophenyl carbonochloridate (1.115 mmol, 225 mg) followed by triethylamine (1.115 mmol, 155 μl, 113 mg). The reaction was stirred for 30 minutes then 1-amino-2-methylpropan-2-ol (2.230 mmol, 199 mg) was added. The reaction was stirred for 2 hours then was chromatographed on silica (eluting with a gradient of dichloromethane to dichloromethane/methanol (8%)) to give the title compound (300 mg). MS (ESI) m/z 564.2 [M+H]+

Provenance & Evidence