Cyclopropanemethanamine → HCID 86670990, compound

Participants

Reaction Steps

A solution of 2-(4-((4-(3-aminobenzyl)piperidin-1-yl)methyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (0.224 mmol, 100 mg) and 4-nitrophenyl carbonochloridate (0.224 mmol, 45.1 mg) in tetrahydrofuran (5 mL) was stirred at room temperature for 30 minutes. Cyclopropylmethanamine (0.453 mmol, 46 μL, 32.2 mg) was added and the reaction was kept at room temperature overnight. The reaction mixture was concentrated under vacuum and residue purified by silica column chromatography (eluent: 2-10% methanol in dichloromethane) to afford the title compound (99 mg).

Provenance & Evidence