Potassium Carbonate → HCID 86670993, compound

Participants

Reaction Steps

1-(Piperidin-4-yl)-1H-benzo[d]imidazol-6-amine (4.62 mmol, 1 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (4.62 mmol, 1.558 g) and potassium carbonate (9.25 mmol, 1.278 g) were combined and stirred in acetonitrile (25 mL) at room temperature for 3 days. The reaction mixture was concentrated at reduced pressure, taken up in dichloromethane, washed with water and concentrated under vacuum. The resulting residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 6% methanol/dichloromethane) to afford the title compound (784 mg). MS (ESI) m/z 473.2 [M+H]+

Provenance & Evidence