Potassium Carbonate → HCID 86670995, compound

Participants

Reaction Steps

1-(Piperidin-4-yl)-1H-benzo[d]imidazol-5-amine, 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (4.82 mmol, 1.624 g) and potassium carbonate (9.64 mmol, 1.332 g) were combined and stirred in acetonitrile (25 mL) at room temperature for 3 days. The reaction mixture was concentrated under vacuum, taken up in dichloromethane, washed with water and concentrated under vacuum. The resulting residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 6% methanol/dichloromethane) to afford the title compound (594 mg). MS (ESI) m/z 473.0 [M+H]+

Provenance & Evidence