Trifluoroacetic acid → 1-(Piperidin-4-yl)-1H-indazol-6-amine

Participants

Reaction Steps

tert-Butyl 4-(6-amino-1H-indazol-1-yl)piperidine-1-carboxylate (6.64 mmol, 2.1 g) was stirred at room temperature in dichloromethane (10 mL)/trifluoroacetic acid (10 mL) for 1 hour. The reaction mixture was concentrated under vacuum. The resulting residue was purified by SCX column to afford the title compound (1.05 g).

Provenance & Evidence