Potassium Carbonate → HCID 86670997, compound

Participants

Reaction Steps

1-(Piperidin-4-yl)-1H-indazol-5-amine (4.85 mmol, 1.05 g), 2-(4-(bromomethyl)phenyl)-1,1,1,3,3,3-hexafluoropropan-2-ol (4.85 mmol, 1.636 g) and potassium carbonate (9.71 mmol, 1.342 g) were combined and stirred in acetonitrile (15 mL) at room temperature for 3 days. The reaction mixture was concentrated under vacuum. The resulting residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 5% methanol/dichloromethane) to afford the title compound (332 mg). MS (ESI) m/z 473.0 [M+H]+

Provenance & Evidence