Sodium Hydroxide → HCID 71769324, compound

Participants

Reaction Steps

To a mixture of methyl 2-(6-(4′-(5-cyclobutyl-1,3,4-oxadiazol-2-ylamino)biphenyl-4-yl)tetrahydro-2H-pyran-3-yl)acetate (43 mg, 0.10 mmol) in THF (0.5 ml) and MeOH (0.5 ml) was added a solution of 1N NaOH (0.29 ml, 0.29 mmol). The mixture was stirred at room temperature for overnight. Afterward, the reaction mixture was concentrated to dryness afford a white solid. The solid was taken up in water to form a slurry and was subsequently filtered. The filtercake was washed with water, dried to afford the title compound (36 mg, 81% yield) as a sodium salt. The ratio of cis to trans isomer was determined to be ˜1:1.2 by NMR studies. HR/MS [M+H]+: found 434.2071, calc. 434.2080. RT: 1.72 (Condition L). HR/MS [M+H]+: found 434.2077, calc. 434.2080. RT: 1.75 (Condition L).

Provenance & Evidence