HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Nitrofurfural → HCID 178518790, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Nitrofurfural | HCID 12774 | — |
| Reactant | 5-[1-(4-Amino-2-fluorophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one | HCID 89650106 | — |
| Catalyst | Acetic Acid | HCID 176 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 178518790 | HCID 178518790 | 81% |
Reaction Steps
5-[1-(4-Amino-2-fluorophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (7e, 0.28 g, 1 mml) on reacting with 5-nitro2-furaldehyde in the presence of catalytic amount of CH3COOH (3 drops) in methanol at 0° C. for 10 h and the obtained solid is filtered, washed with water and recrystallized in ethanol to obtain product 5-[1-(2-fluoro-4-[(E)-1-(5-nitro-2-furyl)methylidene]aminophenyl)-4-piperidyl]-2,3-dihydro-1,3,4-oxadiazol-2-one (9e, 324 mg, 81%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108960B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-999c4ebc4a404f9ea57d21841d6695c5 |
| Source note | uspto-grants-2015_08 |