Benzylamine → HCID 66718451, compound

Participants

Reaction Steps

To a solution of methyl 2-(4-bromophenyl)acrylate (8.2 g, 34 mmol) in methanol (100 mL) at room temperature was added benzylamine (3.7 mL, 34 mmol). The resulting mixture was stirred for 2 days and concentrated. The residue was purified by flash column chromatography on silica gel (chloroform/methanol=90/10 as an eluant) to yield methyl 3-benzylamino-2-(4-bromophenyl)propionate (7.1 g, 20.5 mmol, 60%) as a colorless oil.

Provenance & Evidence