(+)-2-{7-[4-(3-Methyl-[1,2,4]-oxadiazole-5-yl)phenyl]-[1,4]-oxazepane-4-yl}-3-methyl-6-pyrimidin-4-yl-3H-pyrimidin-4-one → 1-Methyl-2-[6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepan-4-yl]-1H-[4,4']bipyrimidinyl-6-one

Participants

Role	Name	HCID	Charge
Reactant	(+)-2-{7-[4-(3-Methyl-[1,2,4]-oxadiazole-5-yl)phenyl]-[1,4]-oxazepane-4-yl}-3-methyl-6-pyrimidin-4-yl-3H-pyrimidin-4-one	HCID 67281351	—
Reactant	6-(4-[1,2,4]Oxadiazol-3-yl-phenyl)-[1,4]oxazepane hydrochloride	HCID 67282208	—
Product	1-Methyl-2-[6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepan-4-yl]-1H-[4,4']bipyrimidinyl-6-one	HCID 67281264	—

Reaction Steps

1-Methyl-2-[6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepan-4-yl]-1H-[4,4′]bipyrimidinyl-6-one was prepared the same procedure as that of 2-{7-[4-(3-methyl-[1,2,4]-oxadiazole-5-yl)phenyl]-[1,4]-oxazepane-4-yl}-3-methyl-6-pyrimidin-4-yl-3H-pyrimidin-4-one except for utilizing 6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepane hydrochloride instead of 7-[4-(3-Methyl-[1,2,4]oxadiazol-5-yl)-phenyl]-[1,4]oxazepane hydrochloride. 1-Methyl-2-[6-(4-[1,2,4]oxadiazol-3-yl-phenyl)-[1,4]oxazepan-4-yl]-1H-[4,4′]bipyrimidinyl-6-one (A086) was obtained as white solid (0.05 g, 0.12 mmol, 59%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09108957B2
Source dataset	uspto-grants-2015_08
ORD ID	ord-bdc48eb8f6a74beabbbdf149bc7bbc64
Source note	uspto-grants-2015_08