反应详情

A mixture of 64.2 g of 1-ethoxycarbonyl-4-hydroxy-4-(3,4-dichlorophenyl)piperidine (X-1) and a solution of 72.4 g of KOH in 700 ml of nBuOH is refluxed for 2 hours and evaporated. The reaction mixture is concentrated under reduced pressure and extracted with ethyl acetate. The organic layer is washed with water, dried and evaporated. The resulting crystalline residue is recrystallized from ethyl acetate to prepare 44.7 g (Yield: 90.0%) of the compound (II-1). mp. 144.5°-146.0° C.

1. customevaporated
2. concentrationThe reaction mixture is concentrated under reduced pressure
3. extractionextracted with ethyl acetate
4. washThe organic layer is washed with water
5. customdried
6. customevaporated
7. customThe resulting crystalline residue is recrystallized from ethyl acetate