HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 515539Generated: October 29, 2026
Dimethylformamide → HCID 118094001, compound
https://huagongshe.com/reaction/515539
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | HCID 118094077 | HCID 118094077 | — |
| Catalyst | Zinc cyanide (Zn(CN)2) | HCID 11186 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Product | HCID 118094001 | HCID 118094001 | — |
Reaction Steps
A mixture of 3-bromo-N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)-2-oxo-1,2-dihydroquinoline-5-sulfonamide (16 mg, 0.034 mmol), zinc cyanide (20 mg, 5 equiv), Pd(PPh3)4 (4 mg, 10 mol %) and DMF was heated at 135° C. for 2 hours. The reaction mixture was purified by preparative HPLC to give 3-cyano-N-cyclopentyl-7-(3,5-dimethylisoxazol-4-yl)-2-oxo-1,2-dihydroquinoline-5-sulfonamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09108953B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-e8ed9e27769c4b49be285ed7d61b3890 |
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| Source note | uspto-grants-2015_08 |
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