反应详情

A solution of 2-aminopyridine (11.314 g, 120.3 mmol) and pyrimidine-5-carboxaldehyde (14.0 g, 129.6 mmol) in chloroform (300 mL) was stirred at room temperature for 15 min. The volatiles were then removed under reduced pressure (1 h at 75° C.) to yield a yellow solid. The crude solid was dissolved in chloroform (300 mL) and the solution was stirred for 15 min. The volatiles were then removed under reduced pressure (1 h at 75° C.) to yield a yellow solid. The crude solid was again dissolved in chloroform (300 mL), the solution was stirred for 15 min, and the volatiles were removed under reduced pressure (1 h at 85° C.) to yield a yellow solid. This solid was dried in a vacuum oven overnight at 80° C. to yield 22.090 g (99.8%) of the title compound.

1. customThe volatiles were then removed under reduced pressure (1 h at 75° C.)
2. customto yield a yellow solid
3. customThe volatiles were then removed under reduced pressure (1 h at 75° C.)
4. customto yield a yellow solid
5. stirringthe solution was stirred for 15 min
6. customthe volatiles were removed under reduced pressure (1 h at 85° C.)
7. customto yield a yellow solid
8. customThis solid was dried in a vacuum oven overnight at 80° C.