反应详情

温度

10 °C

2.90 ml (30.3 mmol) of ethyl chloroformate are added, dropwise in 30 minutes, to a solution of 3.00 g (12.1 mmol) of 6-chloro-2-(4-fluorophenyl)imidazo[1,2-b]pyridazine (CAS: 244081-70-7) and 4.40 ml (60.6 mmol) of pyridazine in 40 ml of dichloromethane at 10° C. The medium is stirred at 10° C. for a further hour and then left to stir for 3 hours. It is then poured into ice-cold water and the product is extracted with ethyl acetate.

1. waitleft
2. stirringto stir for 3 hours
3. additionIt is then poured into ice-cold water
4. extractionthe product is extracted with ethyl acetate