Ammonium formate → 2-(4-fluorophenyl)-6-(hexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine

Participants

Reaction Steps

The mixture of 1.2 g (2.4 mmol) of 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-(1H)-yl)-2-(4-fluorophenyl)-3-(pyridazin-4-yl)-imidazo[1,2-b]pyridazine and 2.3 g (36 mmol) of ammonium formate in 40 ml of methanol is refluxed for 2 hours in the presence of palladium-on-charcoal (10%) containing 50% moisture.

Provenance & Evidence