HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 515564Generated: October 26, 2026
1-Isopropylpiperazine → 2-(4-Fluorophenyl)-6-(4-isopropyl-piperazin-1-yl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine
https://huagongshe.com/reaction/515564
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-Isopropylpiperazine | HCID 78013 | — |
| Reactant | 6-Chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine | HCID 59367701 | — |
| Solvent | 1-Pentanol | HCID 6276 | — |
| Product | 2-(4-Fluorophenyl)-6-(4-isopropyl-piperazin-1-yl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine | HCID 25204797 | — |
Reaction Steps
The mixture of 0.26 g (0.8 mmol) of 6-chloro-2-(4-fluorophenyl)-3-(pyridazin-4-yl)imidazo[1,2-b]pyridazine and 0.66 g (3.2 mmol) of 1-isopropylpiperazine in 6 ml of pentanol is heated in a sealed tube at 130° C. for 10 hours.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09108971B2 |
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| Source dataset | uspto-grants-2015_08 |
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| ORD ID | ord-94a4d94d5131423e927712123a9a4226 |
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| Source note | uspto-grants-2015_08 |
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