Sodium Chloride → HCID 25204729, compound

Participants

Reaction Steps

A mixture of 0.090 g (0.21 mmol) of 2-bromo-3-pyridazin-4-yl-6-(4-pyrrolidin-1-ylpiperidin-1-yl)imidazo[1,2-b]pyridazine, 0.014 g (0.02 mmol) of 1,1′-bis(diphenylphosphino)ferrocenedichloropalladium and 0.043 g (0.27 mmol) of 3,5-difluorophenylboronic acid and of a 2M aqueous solution of cesium carbonate in 2 ml of dioxane is heated at 120° C. for 20 minutes in a microwave oven. 1 ml of a saturated aqueous solution of sodium chloride and 4 ml of ethyl acetate are then injected into the tube. After stirring, the organic phase is removed with a syringe and passed over a sodium sulfate cartridge. The solution is directly injected onto a silica gel column and chromatographed, elution being carried out with a mixture of 0 to 10% of methanol in dichloromethane. 0.037 g of product is thus isolated.

Provenance & Evidence