Ethyl 5-methoxyindole-2-carboxylate → Ethyl 4-bromo-5-methoxy-1H-indole-2-carboxylate

Participants

Reaction Steps

To a suspension of ethyl 5-methoxy-1H-indole-2-carboxylate (5 g, 22.81 mmol) in acetic acid (100 mL) was added bromine (1.169 mL, 22.81 mmol) slowly at room temperature. The reaction mixture was stirred at room temperature for 2 days. The solid was filtered off, washed with acetic acid and hexanes, and dried to give the title compound as a white solid (6.8 g). LCMS m/z=298.6 [M+H]+.

Provenance & Evidence