HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-N-((4-methoxyphenyl)methyl)-5-(trifluoromethyl)-3-pyridinamine → 5-Amino-3-(difluoromethyl)picolinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-N-((4-methoxyphenyl)methyl)-5-(trifluoromethyl)-3-pyridinamine | HCID 25020033 | — |
| Reactant | 5-Bromo-2-chloro-3-(difluoromethyl)pyridine | HCID 60623016 | — |
| Product | 5-Amino-3-(difluoromethyl)picolinonitrile | HCID 67374994 | — |
Reaction Steps
The title compound was synthesized as described in Intermediate 1 (Steps 3-5) using 5-bromo-2-chloro-3-(difluoromethyl)pyridine as the starting material. 1H NMR (400 MHz, DMSO-d6) δ 8.09 (d, 1H), 7.28-7.01 (m, 2H), 6.80 (s, 2H). LCMS [M+H]+ 170.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108944B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-2ee99f1fbd044d36871fec9aadfb762f |
| Source note | uspto-grants-2015_08 |