HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenol → 4-Bromo-2-nitro-1-phenoxybenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenol | HCID 996 | — |
| Reactant | Reserpine | HCID 5770 | — |
| Reactant | 4-Bromo-1-fluoro-2-nitrobenzene | HCID 2736328 | — |
| Reactant | 2-(3-Bromophenoxy)benzonitrile | HCID 28602353 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-Bromo-2-nitro-1-phenoxybenzene | HCID 16109449 | — |
Reaction Steps
The title compound was prepared in a quantitative yield from 5-bromo-2-fluoro-nitrobenzene and phenol in a manner similar to that described for the preparation of 5-bromo-phenoxybenzonitrile: 1H NMR (DMSO-d6, 400 MHz) δ 8.31 9d, 1H), 7.86(dd, 1H), 7.45(t, 2H), 7.25(t, 1H), 7.13(d, 1H), 7.08(d, 2H); RP-HPLC (Hypersil HS, 5 μm, 100 A 4.6×250 mm; 25%-100% acetonitrile—0.05 M ammonium acetate over 10 min, 1 ml/min) tr 12.70 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713474B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-a850122be84941f2be7e2f07be81dafe |
| Source note | uspto-grants-2004_03 |