Silver Nitrate → HCID 178512159, compound

HRID 515863Notes

Reaction equation

HRID 515863 reaction equation
[CH:1]1[C:6]([NH:7][C:8]([NH:10][C:11]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][NH:20][C:21]([NH:23][C:24]([NH:26][C:27]2[CH:28]=[CH:29][C:30]([Cl:33])=[CH:31][CH:32]=2)=[NH:25])=[NH:22])=[NH:12])=[NH:9])=[CH:5][CH:4]=[C:3]([Cl:34])[CH:2]=1.[N+]([O-])([O-])=O.[Ag+:39].[Ag+].S(OOS([O-])(=O)=O)([O-])(=O)=O.[Na+].[Na+]>CO>[Ag+3:39].[CH:28]1[C:27]([NH:26][C:24]([NH:23][C:21]([NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:11]([NH:10][C:8]([NH:7][C:6]2[CH:1]=[CH:2][C:3]([Cl:34])=[CH:4][CH:5]=2)=[NH:9])=[NH:12])=[NH:22])=[NH:25])=[CH:32][CH:31]=[C:30]([Cl:33])[CH:29]=1

Participants

6

Reactant 4

HCID 24470Silver NitrateHCID 62655Sodium PersulfateHCID 104755Silver cationHCID 178512157Chlorohexidine4×

Product 1

HCID 178512159HCID 178512159, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

According to a method described in WO2007/000590, a microcrystalline silver (III)/chlorhexidine complex was prepared. 0.49 mmol of chlorhexidine (1,1′-hexamethylenebis[5-p-chlorphenyl]biguanide) (0.25 g) was dissolved in 25 ml warm methanol and stirred to prepare a chlorhexidine solution. To the chlorhexidine solution was added drop wise an aqueous solution (1.25 ml) containing 0.05 mmol of silver nitrate (0.085 g). To the reaction mixture of silver (I) and chlorhexidine was added drop wise an aqueous solution (1.25 ml) containing 0.99 mmol of sodium persulphate (0.235 g) as oxidizing agent. After the addition of an oxidizing agent, the reaction mixture was warmed until an orange-brown is fully developed. The precipitate was filtered under vacuum and washed three times with warm methanol to yield a microcrystalline silver (III)/chlorhexidine complex.

Workup

  1. customa microcrystalline silver (III)/chlorhexidine complex was prepared
  2. additionAfter the addition of an oxidizing agent
  3. temperaturethe reaction mixture was warmed until
  4. filtrationThe precipitate was filtered under vacuum
  5. washwashed three times with warm methanol
  6. customto yield a microcrystalline silver (III)/chlorhexidine complex

Sources & evidence

ORD record
ord-a17978a14e754dc6a9cf954ffee4d2b7
Source dataset
uspto-grants-2015_08
Patent number
US09108987B2

Reaction notes

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