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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 515871Generated: October 26, 2026

1,3-Benzodioxole-5-carboxaldehyde, 6-bromo- → 6-[4-(Ethoxycarbonyl)-1-methyl-5-trifluoromethyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acid

https://huagongshe.com/reaction/515871

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,3-Benzodioxole-5-carboxaldehyde, 6-bromo-HCID 95062—
ReactantEthyl 2-methyl-3-pyrrolecarboxylateHCID 136747—
Reactant2-Bromo-4-chlorobenzaldehydeHCID 13154710—
Reactantethyl 2-(trifluoromethyl)-1H-pyrrole-3-carboxylateHCID 85684081—
Product6-[4-(Ethoxycarbonyl)-1-methyl-5-trifluoromethyl-1H-pyrrol-2-yl]-1,3-benzodioxole-5-carboxylic acidHCID 117833890—

Reaction Steps

The procedure is in accordance with the process of Preparation 1, replacing in Step A the ethyl 2-methyl-1H-pyrrole-3-carboxylate by ethyl 2-(trifluoromethyl)-1H-pyrrole-3-carboxylate and also the 2-bromo-4-chlorobenzaldehyde used in Step B by 6-bromo-1,3-benzodioxole-5-carbaldehyde.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09108983B2
Source datasetuspto-grants-2015_08
ORD IDord-580f8210768c429e9e30116492270c94
Source noteuspto-grants-2015_08