Lithium Hydroxide → HCID 117833710, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 1.7 g of the compound obtained in Step A (3.77 mmol) in 5 mL of dioxane there is added 0.317 g of LiOH (7.5 mmol) dissolved in 5 mL of water. The batch is heated in a microwave apparatus for 4 hours at 100° C. (power 140 W). The reaction mixture is then filtered and concentrated to dryness. The residue thereby obtained is taken up in dichloromethane (50 mL) and then saturated aqueous NH4Cl solution is added thereto. The organic phase is washed with water and then with brine, dried over MgSO4, filtered and concentrated to dryness. The title product is obtained in the form of a solid and is used directly in the next Step.

Provenance & Evidence