HCID 131733324, compound → HCID 131733323, compound

HRID 515926Notes

Reaction equation

HRID 515926 reaction equation
C([O:8][CH2:9][CH2:10][N:11]1[C:15]([C:16]2[C:24]([C:25]([N:27]3[C@H:36]([CH3:37])[CH2:35][C:34]4[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=4)[CH2:28]3)=[O:26])=[CH:23][C:19]3[O:20][CH2:21][O:22][C:18]=3[CH:17]=2)=[CH:14][C:13]([C:38]([N:40]([C:47]2[CH:52]=[CH:51][C:50]([O:53][Si:54]([C:57]([CH3:60])([CH3:59])[CH3:58])([CH3:56])[CH3:55])=[CH:49][CH:48]=2)[C:41]2[CH:42]=[N:43][N:44]([CH3:46])[CH:45]=2)=[O:39])=[C:12]1[CH3:61])C1C=CC=CC=1>CO.[Pd]>[Si:54]([O:53][C:50]1[CH:49]=[CH:48][C:47]([N:40]([C:41]2[CH:42]=[N:43][N:44]([CH3:46])[CH:45]=2)[C:38]([C:13]2[CH:14]=[C:15]([C:16]3[C:24]([C:25]([N:27]4[C@H:36]([CH3:37])[CH2:35][C:34]5[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=5)[CH2:28]4)=[O:26])=[CH:23][C:19]4[O:20][CH2:21][O:22][C:18]=4[CH:17]=3)[N:11]([CH2:10][CH2:9][OH:8])[C:12]=2[CH3:61])=[O:39])=[CH:52][CH:51]=1)([C:57]([CH3:58])([CH3:60])[CH3:59])([CH3:56])[CH3:55]

Participants

4

Reactant 1

HCID 131733324HCID 131733324, compound

Product 1

HCID 131733323HCID 131733323, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of 6.86 g (8.19 mmol) of the compound of Step A in 70 mL of anhydrous methanol there are added 1.37 g of Pd/C 10%. The batch is degassed for 0.5 hours and then stirred at ambient temperature under dihydrogen pressure (1.5 bar) for 12 hours. The reaction mixture is then filtered and then concentrated to dryness. The expected product is obtained in the form of a solid.

Workup

  1. customThe batch is degassed for 0.5 hours
  2. filtrationThe reaction mixture is then filtered
  3. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-21ec06dc8b0b46268dc61cbda4117cef
Source dataset
uspto-grants-2015_08
Patent number
US09108983B2

Reaction notes

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