Water → Methyl 2-(1H-indazol-6-ylamino)-6-((1R,2S)-2-(tert-butoxycarbonylamino)cyclohexylamino)-4-cyanonicotinate

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A solution of methyl 2-(1H-indazol-6-ylamino)-6-chloro-4-cyanonicotinate (115 mg, 0.351 mmol), tert-butyl (1S,2R)-2-aminocyclohexylcarbamate (90 mg, 0.421 mmol) and Et3N (0.073 mL, 0.526 mmol) in THF (1 mL) was stirred at reflux overnight. Water and EtOAc were added to the mixture. The aqueous phase was extracted with EtOAc. The organic phases were combined, washed with H2O and brine, dried over MgSO4, and evaporated. The residue was rinsed with EtOAc to give the title compound as yellow solid (110 mg, 62.0%). 1H NMR (500 MHz, CDCl3) δ ppm 1.00-1.86 (m, 17 H), 3.84 (s, 3 H), 3.91 (br s, 1 H), 4.12 (br s, 1 H), 6.51 (s, 1 H), 6.63 (d, J=8.79 Hz, 1 H), 7.13 (d, J=8.30 Hz, 1 H), 7.97 (s, 1 H), 8.03 (br s, 1 H), 10.71 (br s, 1 H), 12.87 (br s, 1 H).

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