反应详情

A solution of tert-butyl (1S,2R)-2-(4-(1-methyl-1H-pyrazol-4-yl)-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate (150 mg, 0.352 mmol) and SELECTFLUOR® (150 mg, 0.422 mmol) in DCM (1 mL) and MeOH (1 mL) was stirred at RT overnight. Water was subsequently added and the mixture was extracted with CHCl3 (3×). The organic phases were combined, washed with brine, dried over MgSO4, and evaporated. The residue was purified by preparative HPLC to give the title compound (15 mg, 9.60%). [M+H] calc'd for C22H29FN6O3, 445; found, 445.

1. extractionthe mixture was extracted with CHCl3 (3×)
2. washwashed with brine
3. dry with materialdried over MgSO4
4. customevaporated
5. customThe residue was purified by preparative HPLC