Trifluoroacetic acid → HCID 53250066, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl 3-(6-(2,4-dimethoxybenzyl)-5-oxo-4-(m-tolylamino)-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)propylcarbamate (1.7 mg, 0.003 mmol) in TFA (2 mL) was stirred at 70° C. for 2 h. The mixture was purified by reverse phase preparative HPLC. The fractions were collected and concentrated to give a TFA salt of the title compound as a white solid (0.6 mg, 65%). 1H NMR (500 MHz, CD3OD) δ ppm 2.11-2.26 (m, 2 H), 2.30-2.45 (m, 3 H), 2.92-3.09 (m, 4 H), 4.39 (s, 2 H), 6.98 (d, J=8.34 Hz, 1 H), 7.16-7.35 (m, 1 H), 7.51 (s, 1 H), 7.65 (d, J=8.59 Hz, 1 H). [M+H] calc'd for C16H19N5O, 298; found, 298.

Provenance & Evidence