HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus oxychloride → Methyl 6-chloro-4-cyano-2-(1-ethyl-1H-pyrazol-4-yl)nicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | 4-Cyano-2-(1-ethyl-1H-pyrazol-4-yl)-3-(methoxycarbonyl)pyridine 1-oxide | HCID 67238526 | — |
| Product | Methyl 6-chloro-4-cyano-2-(1-ethyl-1H-pyrazol-4-yl)nicotinate | HCID 58317713 | 90% |
Reaction Steps
A solution of 4-cyano-2-(1-ethyl-1H-pyrazol-4-yl)-3-(methoxycarbonyl)pyridine 1-oxide (210 mg, 0.771 mmol) in POCl3 (2 mL) was heated at 80° C. for 3-4 h. The mixture was concentrated and purified by flash chromatography (SiO2, 10-100% EtOAc in Hexane). The fractions were collected and the solvent was removed in vacuo to give the title compound (201 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108970B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-4ddad670bb4440a78da501086f0d0b4e |
| Source note | uspto-grants-2015_08 |