Diisopropylethylamine → tert-Butyl (1R,2S)-2-(4-chloro-2-(2,4-dimethoxybenzyl)-7-fluoro-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-6-ylamino)cyclohexylcarbamate

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Reaction Conditions

Reaction Steps

A mixture of 4,6-dichloro-2-(2,4-dimethoxybenzyl)-7-fluoro-1H-pyrrolo[3,4-c]pyridin-3(2H)-one (316 mg, 0.851 mmol) and cis-tert-butyl 2-aminocyclohexylcarbamate (365 mg, 1.703 mmol) and DIPEA (0.743 mL, 4.26 mmol) in ACN (2 mL) was stirred at 85° C. for 3 d. The resulting crude material was reconstituted in MeOH (1 mL) and purified by preparative HPLC. The fractions were collected and stripped to dryness via rotary evaporation to yield the title compound (161 mg, 34%). 1H NMR (500 MHz, DMSO-d6) δ ppm 1.35 (br s, 10 H), 1.58 (br s, 2 H), 1.76 (br s, 2 H), 3.71-3.90 (m, 11 H), 4.33 (br s, 2 H), 4.51 (br s, 2 H), 6.43-6.72 (m, 3 H), 6.87 (br s, 1 H), 7.07 (br s, 1 H). [M+H] calc'd for C27H34ClFN4O5, 549; found, 549.

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