HCID 89870782, compound → HCID 123966202, compound

HRID 516156Notes

Reaction equation

HRID 516156 reaction equation
[NH:1]1[CH2:4][CH:3]([CH2:5][N:6]2[C:10]3=[N:11][CH:12]=[N:13][C:14]([NH2:15])=[C:9]3[C:8]([C:16]#[C:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[CH:19]=3)=[N:7]2)[CH2:2]1.NC1N=CN=C2N(CC3[CH2:54][N:53]([C:55](=O)[CH:56]=[CH2:57])[CH2:52]3)N=C(C#CC3C=C(OC)C=C(OC)C=3)C=12.[CH3:59][O:60]C1C=C(C#CC2C3C(=NC=NC=3N)N([C@H]3CCNC3)N=2)C=C(OC)C=1>>[NH2:15][C:14]1[N:13]=[CH:12][N:11]=[C:10]2[N:6]([CH2:5][CH:3]3[CH2:4][N:1]([C:59](=[O:60])[CH:57]=[CH:56][CH2:55][N:53]([CH3:52])[CH3:54])[CH2:2]3)[N:7]=[C:8]([C:16]#[C:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[CH:21]=[C:20]([O:26][CH3:27])[CH:19]=3)[C:9]=12

Participants

4

Reactant 3

HCID 89870782HCID 89870782, compoundHCID 89870811HCID 89870811, compoundHCID 89870905HCID 89870905, compound

Product 1

HCID 123966202HCID 123966202, compound

Procedure

In accordance with Example 4, except that 1-(azetidin-3-ylmethyl)-3-((3,5-dimethoxyphenyl)ethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (i.e., an intermediate obtained in Example 29) was used in place of (S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, the title compound was obtained as a light-yellow, amorphous substance. Table 1 shows the physical properties thereof.

Sources & evidence

ORD record
ord-549d251141064a5eb31f453506e3e80e
Source dataset
uspto-grants-2015_08
Patent number
US09108973B2

Reaction notes

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