HCID 89870782, compound → HCID 123714811, compound

HRID 516158Notes

Reaction equation

HRID 516158 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]#[C:12][C:13]2[C:21]3[C:16](=[N:17][CH:18]=[N:19][C:20]=3[NH2:22])[N:15]([CH2:23][CH:24]3[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]3)[N:14]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.NC1N=CN=C2N([CH2:52][CH:53]3C[CH2:57][N:56]([C:59](=O)C=C)[CH2:55][CH2:54]3)N=C(C#CC3C=C(OC)C=C(OC)C=3)C=12.C[O:64]C1C=C(C#CC2C3C(=NC=NC=3N)N([C@H]3CCNC3)N=2)C=C(OC)C=1>>[NH2:22][C:20]1[N:19]=[CH:18][N:17]=[C:16]2[N:15]([CH2:23][CH:24]3[CH2:29][CH2:28][N:27]([C:52](=[O:64])[CH:53]=[CH:54][CH2:55][N:56]([CH3:59])[CH3:57])[CH2:26][CH2:25]3)[N:14]=[C:13]([C:12]#[C:11][C:5]3[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=3)[C:21]=12

Participants

4

Reactant 3

HCID 89870782HCID 89870782, compoundHCID 89870989HCID 89870989, compoundHCID 89871025HCID 89871025, compound

Product 1

HCID 123714811HCID 123714811, compound

Procedure

In accordance with Example 4, except that 3-((3,5-dimethoxyphenyl)ethynyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (i.e., the intermediate obtained in Example 33) was used in place of (S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, the title compound was obtained as a light-yellow, amorphous substance. Table 1 shows the physical properties thereof.

Sources & evidence

ORD record
ord-afd905dd2a79457fb484dc29091916f1
Source dataset
uspto-grants-2015_08
Patent number
US09108973B2

Reaction notes

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