Propionyl chloride → HCID 89870870, compound

HRID 516188Notes

Reaction equation

HRID 516188 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11]#[C:12][C:13]2[C:21]3[C:16](=[N:17][CH:18]=[N:19][C:20]=3[NH2:22])[N:15]([C@H:23]3[CH2:27][CH2:26][NH:25][CH2:24]3)[N:14]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.[C:28](Cl)(=[O:31])[CH2:29][CH3:30]>>[NH2:22][C:20]1[N:19]=[CH:18][N:17]=[C:16]2[N:15]([C@H:23]3[CH2:27][CH2:26][N:25]([C:28](=[O:31])[CH2:29][CH3:30])[CH2:24]3)[N:14]=[C:13]([C:12]#[C:11][C:5]3[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[C:7]([O:9][CH3:10])[CH:6]=3)[C:21]=12

Participants

3

Reactant 2

HCID 62324Propionyl chlorideHCID 89870782HCID 89870782, compound

Product 1

HCID 89870870HCID 89870870, compound

Procedure

In accordance with Example 1, (S)-3-((3,5-dimethoxyphenyl)ethynyl)-1-(pyrrolidin-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine and propionyl chloride were used to obtain the title compound as a white solid. Table 2 shows the physical properties thereof.

Sources & evidence

ORD record
ord-f2baa86c512d4837a883798098f8f424
Source dataset
uspto-grants-2015_08
Patent number
US09108973B2

Reaction notes

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