HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 3-(2-Fluorophenyl)-isoxazole-5-carbonyl Chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(2-Fluorophenyl)-1,2-oxazole-5-carboxylic acid | HCID 3160255 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2-Fluorophenyl)-isoxazole-5-carbonyl Chloride | HCID 86705140 | 94.6% |
Reaction Steps
Oxalyl chloride (0.07 mL, 0.74 mmol) was added dropwise to a stirred solution of 3-(2-fluorophenyl)isoxazole-5-carboxylic acid (77 mg, 370 μmol) in THF (10 mL). The mixture was stirred at room temperature for 2 hours, then concentrated to yield the title compound (79 mg), which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09108934B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-b310e7e1b1c148e69bb2336af585ff11 |
| Source note | uspto-grants-2015_08 |