Hydrochloric Acid → HCID 90410741, compound

Participants

Reaction Steps

A solution of methyl 4-acetamido-6-(4-bromo-2,3,6-trifluorophenyl)-3-chloropicolinate (50 mg, 0.122 mmol, 1.0 eq) and sodium hydroxide (14 mg, 0.366 mmol, 3.0 eq) in THF:MeOH:H2O (1:1:0.5, 2.5 mL) was stirred at 20° C. for 2 h. The reaction mixture was acidified to pH 4-5 using 1.5 N HCl and extracted with EtOAc (2×). The combined organic extract was dried over anhydrous Na2SO4 and evaporated to dryness under reduced pressure to provide the title compound as a pale brown solid (30 mg, 65%).

Provenance & Evidence