1-Bromo-3-methylbutane → 4-Bromo-1-isopentylpyridin-2(1H)-one

HRID 516617Notes

Reaction equation

HRID 516617 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][CH:9]2[CH2:11][CH2:10]2)[C:4](=[O:12])[CH:3]=1.O[C:14]1C=CN(CCC(C)C)C(=O)C=1.C1(CN2C=CC(O)=CC2=O)CC1.C(OC1C=CNC(=O)C=1)C1C=CC=CC=1.BrCCC(C)C>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:8][CH2:9][CH:11]([CH3:10])[CH3:14])[C:4](=[O:12])[CH:3]=1

Participants

6

Reactant 5

HCID 78911-Bromo-3-methylbutaneHCID 36077244-Benzyloxy-2(1H)-pyridoneHCID 585545154-Bromo-1-(cyclopropylmethyl)pyridin-2(1H)-oneHCID 594970981-(Cyclopropylmethyl)-4-hydroxypyridin-2(1H)-oneHCID 668856654-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one

Product 1

HCID 594970904-Bromo-1-isopentylpyridin-2(1H)-one

Procedure

Intermediate D7 was prepared following the same procedure implemented for the synthesis of D3, using 4-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one as starting material, which was prepared by the same method used for the synthesis of intermediate D2, by reaction of 4-benzyloxy-1H-pyridin-2-one with 1-bromo-3-methylbutane.

Workup

  1. customwas prepared by the same method

Sources & evidence

ORD record
ord-fa03a9a31b564fcc872da48b438efe37
Source dataset
uspto-grants-2015_08
Patent number
US09114138B2

Reaction notes

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