HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 1-butyl-4-hydroxy-1H-pyridine-2-one | HCID 59497076 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone | HCID 59497074 | 83% |
Reaction Steps
N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction was stirred at room temperature overnight and then it was concentrated in vacuo. The crude product was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D8 (2.0 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09114138B2 |
| Source dataset | uspto-grants-2015_08 |
| ORD ID | ord-d1a09d08328e43e1a0428aa54f626a7a |
| Source note | uspto-grants-2015_08 |