反应详情

N-Iodosuccinimide (2.64 g, 11.74 mmol) was added to a solution of intermediate D1 (3.0 g, 11.74 mmol) in acetic acid (40 ml). The reaction mixture was stirred at room temperature for 1 hour, after which it was concentrated in vacuo, purified by flash chromatography (silica gel; 0-3% methanol/DCM as eluent) and finally recrystallized from diethyl ether to afford intermediate D10 (4.12 g, 92%) as a solid.

1. concentrationafter which it was concentrated in vacuo
2. custompurified by flash chromatography (silica gel; 0-3% methanol/DCM as eluent)
3. customfinally recrystallized from diethyl ether
4. customto afford intermediate D10 (4.12 g, 92%) as a solid