HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 6-Ethynyl-3,4-dihydro-4,4-dimethylspiro[2H-1-benzopvran-2,1'-cyclopropane]
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | [4-(8-Cyclopropyl-2,2,4,4-tetramethyl-chroman-6-yl-ethvnyl)-2-fluorophenyl]acetic acid ethyl ester | HCID 69548621 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Ethynyl-3,4-dihydro-4,4-dimethylspiro[2H-1-benzopvran-2,1'-cyclopropane] | HCID 22568894 | — |
Reaction Steps
Following general procedure E and using 3,4-dihydro-4,4-dimethyl-6-(trimethylsilanyl)ethynylspiro[2H-1-benzopyran-2,1′-cyclopropane] (Intermediate 37, 0.4 g, 1.42 mmol), potassium carbonate (0.98 g, 7.1 mmol) and methanol, the title compound was obtained as a yellow oil (0.3 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06713647B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-1fc94e769e224a6595125b339d2a9d59 |
| Source note | uspto-grants-2004_03 |